• Coronary artery disease is characterized by a dysfunction of the endothelial cells that form the innermost lining of all blood vessels.
• A new study has identified five biological pathways regulated by a few genes that could potentially play a prominent role in coronary artery disease through their involvement in endothelial cell function.
• Notably, these pathways included genes whose role in coronary artery disease has not been previously demonstrated.
• One of the genes in these pathways, TLNRD1, plays an essential role in endothelial function, cardiovascular health, and potentially coronary artery disease, according to the study.
• These findings could lead to the development of novel therapies targeting endothelial cell dysfunction in coronary artery disease.
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By Deep Shukla on February 15, 2024

Fact checked by Jill Seladi-Schulman, Ph.D.